A large number of cellular proteins bind ATP, frequently utilizing the free energy of ATP hydrolysis to drive specific biological reactions. Recently, a family of closely related ATP‐binding proteins has been identified, the members of which share considerable sequence identity. These proteins, from both prokaryotic and eukaryotic sources, presumably had a common evolutionary origin and include the product of the white locus of Drosophila, the P‐glycoprotein which confers multidrug resistance on mammalian tumours, and prokaryotic proteins associated with such diverse (...) processes as membrane transport, cell division, nodulation and DNA repair. A comparison of these various proteins provides valuable insights into the function and evolution of the multicomponent systems with which they are associated. (shrink)

RationaleSurrogates of critically ill patients often have inaccurate expectations about prognosis. Yet there is little research on how intensive care unit clinicians should discuss prognosis, and existing expert opinion-based recommendations give only general guidance that has not been validated with surrogate decision makers.ObjectiveTo determine the perspectives of key stakeholders regarding how prognostic information should be conveyed in critical illness.MethodsThis was a multicenter study at three academic medical centers in California, Pennsylvania, and Washington. One hundred eighteen key stakeholders completed in-depth semistructured (...) interviews. Participants included 47 surrogates of adult patients with acute respiratory distress syndrome; 45 clinicians working in study ICUs, including physicians, nurses, social workers, and spiritual care providers; and 26 experts in health communication, decision science, ethics, family-centered care, geriatrics, healthcare disparities, palliative care, psychology, psychiatry, and critical care.Measurements and main resultsThere was broad support among surrogates for existing expert recommendations, including truthful prognostic disclosure, emotional support, tailoring the disclosure strategy to each family's needs, and checking for understanding. In addition, stakeholders offered suggestions that add specificity to existing recommendations, including: In addition to conveying prognostic estimates, clinicians should help families "see the prognosis for themselves" by showing families radiographic images and explaining the clinical significance of physical manifestations of severe disease at the bedside. Many physicians did not support using numeric estimates to convey prognosis to families, whereas many surrogates, clinicians from other disciplines, and experts believed numbers could be helpful. Clinicians should conceptualize prognostic communication as an iterative process that begins with a preliminary mention of the possibility of death early in the ICU stay and becomes more detailed as the clinical situation develops. Although prognostic information should be initially disclosed by physicians, other members of the multidisciplinary team-nurses, social workers, and spiritual care providers-should be given explicit role responsibilities to reinforce physicians' prognostications and help families process a poor prognosis emotionally.ConclusionsFamily members, clinicians, and experts identified specific communication behaviors that clinicians should use to discuss prognosis in the critical care setting. These findings extend existing opinion-based recommendations and should guide interventions to improve communication about prognosis in ICUs. (shrink)

Darwinian Evolution and Classical Liberalism brings together a collection of new essays that examine the multifaceted ferment between Darwinian biology and classical liberalism.

There is what might be called a ‘majority position’ in the history of Western philosophy according to which causes are sufficient for or ‘necessitate’ their effects. However, there is also a singificant ‘minority position’ according to which causes are necessary relative to their effects. The second/third century A.D. Peripatetic Alexander of Aphrodisias is an ancient representative of the minority position. He attributes his own view — with some justification, I shall suggest – to Aristotle. This paper has two, somewhat loosely (...) connected purposes. The first is to explore the origin of the conception of ‘causes’ as necessary conditions in Aristotle, particularly in On Generation and Corruption 2.11 and Posterior Analytics 2.12, and the development and use of the conception in Alexander's De fato. The second purpose of the paper is to explore and criticize a sophisticated contemporary version of the conception of causes as ‘necessary in the circumstances,’ that of J.L. Mackie. (shrink)

There is what might be called a ‘majority position’ in the history of Western philosophy according to which causes are sufficient for or ‘necessitate’ their effects. However, there is also a singificant ‘minority position’ according to which causes are necessary relative to their effects. The second/third century A.D. Peripatetic Alexander of Aphrodisias is an ancient representative of the minority position. He attributes his own view — with some justification, I shall suggest – to Aristotle. This paper has two, somewhat loosely (...) connected purposes. The first is to explore the origin of the conception of ‘causes’ as necessary conditions in Aristotle, particularly in On Generation and Corruption 2.11 and Posterior Analytics 2.12, and the development and use of the conception in Alexander's De fato. The second purpose of the paper is to explore and criticize a sophisticated contemporary version of the conception of causes as ‘necessary in the circumstances,’ that of J.L. Mackie. (shrink)

SummaryThis paper develops a semantical account of sentences containing performative principal verbs in which these verbs are analyzed as indexical expressions: the proposition picked out by a sentence containing a performative verb depends on aspects of the context of use of the sentence; and these same aspects of context of use also determine the truth value of the proposition picked out. A two‐dimensional modal operator is utilized in analyzing non‐ performative sentences that contain principal verb which, in other contexts, have (...) performative uses. Thus, the analysis developed accounts for the performative — non‐performative distinction within a formal semantic‐pragmatic framework; the more common approach of relegating the distinction to the somewhat vague realm of ‘language use’ is avoided.RésuméCet article développe un traitement sémantique des phrases contenant un verbe principal performatif. Ces verbes sont analysés comme des expressions indicées: la proposition sélectionnée par une phrase contenant un verbe performatif dépend du contexte d'usage de cette phrase; et ces mêmes aspects du contexte d'usage déterminent également la valeur de vérité de la proposition sélectionnée. Un opérateur modal à deux dimensions est utilisé pour l'analyse de phrases non‐performatives contenant un verbe principal performatif dans d'autres contextes. L'analyse développée rend ainsi compte de la distinction performatif — non‐performatif dans un cadre sémantico‐pragmatique; on évite ainsi la solution habituelle consistant à reléguer cette distinction dans le domaine plutôt vague de l'usage linguistique.ZusammenfassungEs wird eine semantische Darstellung von Sätzen entwickelt, die performative Hauptverben enthalten, indem diese Verben als indexikale Ausdrücke analysiert werden: die Proposition, die durch einen Satz mit einem performativen Verb bezeichnet wird, hängt von Aspekten des Gebrauchskontextes des Satzes ab; und gerade diese Aspekte bestimmen auch den Wahrheitswert der Proposition. Ein zweidimensionaler Modaloperator wird verwendet, um nicht‐performative Sätze zu analysieren, die Hauptverben enthalten, welche — in andern Kontexten — einen performativen Gebrauch haben. Auf diese Weise gibt die entwickelte Analyse innerhalb eines formalen semantisch‐syntaktischen Rahmenwerkes Rechenschaft über die Unterscheidung performativ — nicht‐performativ; man vermeidet dadurch das übliche Vorgehen, die Unterscheidung in den etwas vagen Bereich des sog. 〈Sprachgebrauchs〉 abzuschieben. (shrink)

IntroductionResilience is a factor in how youth respond to adversity. The 88-item Adolescent Resilience Questionnaire is a comprehensive, multi-dimensional self-report measure of resilience developed with Australian youth.MethodsUsing a cross-sectional adolescent population, confirmatory factor analysis was conducted to replicate the original factor structure. Over half of the adolescents were non-white and 9th graders with a mean age of 15.5.ResultsOur exploratory factor analysis shortened the measure for which we conducted the psychometric analyses. The original factor structure was not replicated. The exploratory (...) factor analysis provided a 49-item measure. Internal consistency reliability for all 12 factors ranged from acceptable. The revised factor total scores were highly and significantly correlated with item–total correlation coefficients.ConclusionThis revised shorter 49-item version of the Adolescent Resilience Questionnaire could be deployed and has acceptable psychometric properties. (shrink)

A high percent of oxidative energy metabolism is needed to support brain growth during infancy. Unhealthy diets and limited nutrition, as well as other environmental insults, can compromise these essential developmental processes. In particular, iron deficiency anemia has been found to undermine both normal brain growth and neurobehavioral development. Even moderate ID may affect neural maturation because when iron is limited, it is prioritized first to red blood cells over the brain. A primate model was used to investigate the neural (...) effects of a transient ID and if deficits would persist after iron treatment. The large size and postnatal growth of the monkey brain makes the findings relevant to the metabolic and iron needs of human infants, and initiating treatment upon diagnosis of anemia reflects clinical practice. Specifically, this analysis determined whether brain maturation would still be compromised at 1 year of age if an anemic infant was treated promptly once diagnosed. The hematology and iron status of 41 infant rhesus monkeys was screened at 2-month intervals. Fifteen became ID; 12 met clinical criteria for anemia and were administered iron dextran and B vitamins for 1–2 months. MRI scans were acquired at 1 year. The volumetric and diffusion tensor imaging measures from the ID infants were compared with monkeys who remained continuously iron sufficient. A prior history of ID was associated with smaller total brain volumes, driven primarily by significantly less total gray matter and smaller GM volumes in several cortical regions. At the macrostructual level, the effect on white matter volumes was not as overt. However, DTI analyses of WM microstructure indicated two later-maturating anterior tracts were negatively affected. The findings reaffirm the importance of iron for normal brain development. Given that brain differences were still evident even after iron treatment and following recovery of iron-dependent hematological indices, the results highlight the importance of early detection and preemptive supplementation to limit the neural consequences of ID. (shrink)

An emerging class of theories concerning the functional structure of the brain takes the reuse of neural circuitry for various cognitive purposes to be a central organizational principle. According to these theories, it is quite common for neural circuits established for one purpose to be exapted (exploited, recycled, redeployed) during evolution or normal development, and be put to different uses, often without losing their original functions. Neural reuse theories thus differ from the usual understanding of the role of neural plasticity (...) (which is, after all, a kind of reuse) in brain organization along the following lines: According to neural reuse, circuits can continue to acquire new uses after an initial or original function is established; the acquisition of new uses need not involve unusual circumstances such as injury or loss of established function; and the acquisition of a new use need not involve (much) local change to circuit structure (e.g., it might involve only the establishment of functional connections to new neural partners). Thus, neural reuse theories offer a distinct perspective on several topics of general interest, such as: the evolution and development of the brain, including (for instance) the evolutionary-developmental pathway supporting primate tool use and human language; the degree of modularity in brain organization; the degree of localization of cognitive function; and the cortical parcellation problem and the prospects (and proper methods to employ) for function to structure mapping. The idea also has some practical implications in the areas of rehabilitative medicine and machine interface design. (shrink)

It is often argued that belief is partly constituted by a norm of truth. Most recent discussions have assumed that the norm is deontic concerning what may or ought to be believed. I criticize two proposals, one canvassed by Krister Bykvist and Anandi Hattiangadi, and the other defended by Daniel Whiting. Instead, I argue in favour of an evaluative norm, according to which we would do well to believe the truth. I show that an evaluative norm fares better than its (...) deontic competitors with respect to the demandingness of truth, the aim of truth, and epistemic blame. -/- On soutient souvent que la croyance est en partie constituée par une norme de vérité. La plupart des discussions récentes ont supposé que la norme est déontique concernant ce qui peut ou doit être cru. Je critique deux propositions, l’une mise de l’avant par Krister Bykvist et Anandi Hattiangadi, et l’autre défendue par Daniel Whiting. Je plaide plutôt en faveur d’une norme évaluative selon laquelle nous ferions bien de croire la vérité. Je montre qu’une norme évaluative réussit mieux que ses concurrentes déontiques en ce qui a trait au caractère exigeant de la vérité, au but de la vérité et au blâme épistémique. (shrink)

Readers of C.L.R. James are familiar with the thinker’s careful reading of Melville’s Moby-Dick in his text Mariners, Renegades, and Castaways. In that work James proposes that Melville exposes the foundations of societal level fascism as exemplified by the monomaniacal purpose of Ahab. The purpose of this effort is to push further into the concept of societal division as exemplified by Moby-Dick by proposing that Melville is taking on the discourse of color (black vs. white) and its relationship to (...) ontological value (bad vs. good) by imploding the internal logic of Plato’s Phaedrus. What concerns this project is the relationship between the phenotypic “blackness” of the characters of African descent in Moby-Dick and ways in which Melville endeavors to destabilize skin color in the western imaginary as a means to correct the negative consequences of this flattening of the hierarchical nature of society on the part of Ahab. (shrink)

The nature of cognition is being re-considered. Instead of emphasizing formal operations on abstract symbols, the new approach foregrounds the fact that cognition is, rather, a situated activity, and suggests that thinking beings ought therefore be considered first and foremost as acting beings. The essay reviews recent work in Embodied Cognition, provides a concise guide to its principles, attitudes and goals, and identifies the physical grounding project as its central research focus.

__Adolescents at Schoo_l brings together the perspectives of scholars, educators, and researchers to address the many issues that affect adolescents’ emerging identities, especially in relation to students’ experience of and engagement with school._ The book offers current and preservice teachers a practical understanding of the concept of identity development, particularly as impacted by such factors as race, ethnicity, gender, sexual orientation, ability/disability, immigration, and social class. This third edition includes new chapters on boys’ emotional lives, risk and resilience in girls, (...) the experiences of undocumented immigrant students, Muslim-American youth, and income inequality; features on “teaching while white”; and an extensively updated chapter on LGBTQ+ students. The book expands on the strengths and insights of the previous editions while also touching on issues highly relevant to contemporary youth such as social media, youth activism, and immigration. A practical and insightful volume, _Adolescents at School_ points to ways to foster the success of every student in our schools and classrooms. (shrink)

In this paper, I summarize an emerging debate in the cognitive sciences over the right taxonomy for understanding cognition – the right theory of and vocabulary for describing the structure of the mind – and the proper role of neuroscientific evidence in specifying this taxonomy. In part because the discussion clearly entails a deep reconsideration of the supposed autonomy of psychology from neuroscience, this is a debate in which philosophers should be interested, with which they should be familiar, and to (...) which they should contribute. Here, I outline some of the positions being advocated, and reflect on some of the possible implications of this work both for scientific and folk psychology. (shrink)

To accept that cognition is embodied is to question many of the beliefs traditionally held by cognitive scientists. One key question regards the localization of cognitive faculties. Here we argue that for cognition to be embodied and sometimes embedded, means that the cognitive faculty cannot be localized in a brain area alone. We review recent research on neural reuse, the 1/f structure of human activity, tool use, group cognition, and social coordination dynamics that we believe demonstrates how the boundary between (...) the different areas of the brain, the brain and body, and the body and environment is not only blurred but indeterminate. In turn, we propose that cognition is supported by a nested structure of task-specific synergies, which are softly assembled from a variety of neural, bodily, and environmental components (including other individuals), and exhibit interaction dominant dynamics. (shrink)

Neural reuse is a form of neuroplasticity whereby neural elements originally developed for one purpose are put to multiple uses. A diverse behavioral repertoire is achieved by means of the creation of multiple, nested, and overlapping neural coalitions, in which each neural element is a member of multiple different coalitions and cooperates with a different set of partners at different times. Neural reuse has profound implications for how we think about our continuity with other species, for how we understand the (...) similarities and differences between psychological processes, and for how best to pursue a unified science of the mind.After Phrenology: Neural Reuse and the Interactive Brain surveys the terrain and advocates for a series of reforms in psychology and cognitive neuroscience. The book argues that, among other things, we should capture brain function in a multidimensional manner, develop a new, action-oriented vocabulary for psychology, and recognize that higher-order cognitive processes are built from complex configurations of already evolved circuitry. (shrink)

However, other leading philosophers of the era--such as David Hume, Adam Smith, and J.G. Herder--placed greater emphasis on feeling, seeing moral and political ...

This essay introduces the massive redeployment hypothesis, an account of the functional organization of the brain that centrally features the fact that brain areas are typically employed to support numerous functions. The central contribution of the essay is to outline a middle course between strict localization on the one hand, and holism on the other, in such a way as to account for the supporting data on both sides of the argument. The massive redeployment hypothesis is supported by case studies (...) of redeployment, and compared and contrasted with other theories of the localization of function. (shrink)

This essay introduces the massive redeployment hypothesis, an account of the functional organization of the brain that centrally features the fact that brain areas are typically employed to support numerous functions. The central contribution of the essay is to outline a middle course between strict localization on the one hand, and holism on the other, in such a way as to account for the supporting data on both sides of the argument. The massive redeployment hypothesis is supported by case studies (...) of redeployment, and compared and contrasted with other theories of the localization of function. (shrink)

Abstract: The massive redeployment hypothesis (MRH) is a theory about the functional topography of the human brain, offering a middle course between strict localization on the one hand, and holism on the other. Central to MRH is the claim that cognitive evolution proceeded in a way analogous to component reuse in software engineering, whereby existing components-originally developed to serve some specific purpose-were used for new purposes and combined to support new capacities, without disrupting their participation in existing programs. If the (...) evolution of cognition was indeed driven by such exaptation, then we should be able to make some specific empirical predictions regarding the resulting functional topography of the brain. This essay discusses three such predictions, and some of the evidence supporting them. Then, using this account as a background, the essay considers the implications of these findings for an account of the functional integration of cognitive operations. For instance, MRH suggests that in order to determine the functional role of a given brain area it is necessary to consider its participation across multiple task categories, and not just focus on one, as has been the typical practice in cognitive neuroscience. This change of methodology will motivate (even perhaps necessitate) the development of a new, domain-neutral vocabulary for characterizing the contribution of individual brain areas to larger functional complexes, and direct particular attention to the question of how these various area roles are integrated and coordinated to result in the observed cognitive effect. Finally, the details of the mix of cognitive functions a given area supports should tell us something interesting not just about the likely computational role of that area, but about the nature of and relations between the cognitive functions themselves. For instance, growing evidence of the role of “motor” areas like M1, SMA and PMC in language processing, and of “language” areas like Broca’s area in motor control, offers the possibility for significantly reconceptualizing the nature both of language and of motor control. (shrink)

This paper argues that research on the business case for corporate social responsibility (CSR) must account for the path dependent nature of firm-stakeholderrelations, and develops the construct of stakeholder influence capacity (SIC) to fill this void. SIC helps to explain why the effects of CSR on corporate financial performance (CFP) vary across firms and across time, therein providing a missing link in the study of the business case. This paper distinguishes CSR from related and confounded corporate resource allocations and from (...) corporate social performance (CSP), then incorporates SIC into a model that explains how acts of CSR are transformed into CFP through stakeholder relationships. This paper also develops a set of propositions to aid future research on the contingencies that produce variable financial returns to investments in CSR. (shrink)

Do firms benefit from their voluntary efforts to alleviate the many problems confronting society? A vast literature establishing a “business case” for corporate social responsibility appears to find that usually they do. However, as argued herein, the business case literature has established only that firms usually benefit from responding to the demands of their primary stakeholders. The nature of the relationship between the interests of business and those of broader society, beyond a subset of powerful primary stakeholders, remains an open (...) question despite this vast literature. This article develops a set of propositions that highlight constraints on firms’ ability to profit from CSR and outlines a set of managerial challenges on which researchers must focus their attention to truly determine whether and when firms can profit by responding to the needs of society. (shrink)

“The physics of representation” aims to define the word “representation” as used in the neurosciences, argue that such representations as described in neuroscience are related to and usefully illuminated by the representations generated by modern neural networks, and establish that these entities are “representations in good standing”. We suggest that Poldrack succeeds in, exposes some tensions between the broad use of the term in neuroscience and the narrower class of entities that he identifies in the end, and between the meaning (...) of “representation” in neuroscience and in psychology in, and fails in. This results in some hard choices: give up on the broad scope of the term in neuroscience or continue to embrace the broad, psychologically inflected sense of the term, and deny the entities generated by neural nets are representations in the relevant sense. (shrink)

b>. Recent findings in cognitive science suggest that the epistemic subject is more complex and epistemically porous than is generally pictured. Human knowers are open to the world via multiple channels, each operating for particular purposes and according to its own logic. These findings need to be understood and addressed by the philosophical community. The current essay argues that one consequence of the new findings is to invalidate certain arguments for epistemic anti-realism.

Trade associations operate under the premise of advancing the shared interests of their member firms. How well do they fulfill this role? This article measures the activity of 148 major industry trade associations over time and relates this activity to the performance of the relevant industries and dominant firms within them. Findings suggest that trade association spending increases when the profitability of the four largest firms in an industry decreases, but spending is unrelated to the profitability of the industry overall. (...) This implies that large firms exert control over trade association agendas and may use these communal organizations to advance their own interests rather than the shared interests of the entire industry. Moreover, it points to the need for further development of the currently anemic management literature on the activities of trade associations. (shrink)

In this paper we provide an account of the structural underpinnings of self-awareness. We offer both an abstract, logical account.

As part of the ongoing attempt to fully naturalize the concept of human being--and, more specifically, to re-center it around the notion of agency--this essay discusses an approach to defining the content of representations in terms ultimately derived from their central, evolved function of providing guidance for action. This 'guidance theory' of representation is discussed in the context of, and evaluated with respect to, two other biologically inspired theories of representation: Dan Lloyd's dialectical theory of representation and Ruth Millikan's biosemantics.

Multi-voxel pattern analysis (MVPA) is a popular analytical technique in neuroscience that involves identifying patterns in fMRI BOLD signal data that are predictive of task conditions. But the technique is also frequently used to make inferences about the regions of the brain that are most important to the tasks in question, and our analysis shows that this is a mistake. MVPA does not provide a reliable guide to what information is being used by the brain during cognitive tasks, nor where (...) that information is. This is due in part to inherent run to run variability in the decision space generated by the classifier, but there are also several other issues, discussed below, that make inference from the characteristics of the learned models to relevant brain activity deeply problematic. These issues have significant implications both for many papers already published, and for how the field uses this technique in the future. (shrink)

Over the last decade, managers have increasingly emphasised the creation of tangible measures of intangible organisational properties. Many major corporations now include measures for intellectual capital, knowledge capital, reputational capital, and other such intangible assets on their financial ledgers. Counter to the rubric that ‘If it doesn’t get measured, it doesn’t get done,’ we argue that some intangibles are truly intangible, and attempts to apply tangible measures to them creates undue organisational stress and harms the underlying asset. Instead, managers may (...) better foster the growth of intangible assets by placing less emphasis on outcome measurement and more emphasis on the process. Using New York University’s Office of Community Service as a case study, we illustrate how a Zen approach can augment tangible measures to create a truly ‘balanced’ organisational strategy. American firms have widely adopted the strict measurement practices of Japanese firms, but few have adopted the Eastern practice of Zen. A Zen approach fosters trust and provides flexibility that allows organisations to better achieve success in the long run. (shrink)

Over the last decade, managers have increasingly emphasised the creation of tangible measures of intangible organisational properties. Many major corporations now include measures for intellectual capital, knowledge capital, reputational capital, and other such intangible assets on their financial ledgers. Counter to the rubric that ‘If it doesn’t get measured, it doesn’t get done,’ we argue that some intangibles are truly intangible, and attempts to apply tangible measures to them creates undue organisational stress and harms the underlying asset. Instead, managers may (...) better foster the growth of intangible assets by placing less emphasis on outcome measurement and more emphasis on the process. Using New York University’s Office of Community Service as a case study, we illustrate how a Zen approach can augment tangible measures to create a truly ‘balanced’ organisational strategy. American firms have widely adopted the strict measurement practices of Japanese firms, but few have adopted the Eastern practice of Zen. A Zen approach fosters trust and provides flexibility that allows organisations to better achieve success in the long run. (shrink)

The representations formed by the ventral and dorsal streams of a prelinguistic agent will tend to be too qualitatively similar to support the distinct roles required by PREDICATE(x) structure. We suggest that the attachment of qualities to objects is not a product of the combination of these separate processing streams, but is instead a part of the processing required in each. In addition, we suggest that the formation of objective predicates is inextricably bound up with the emergence of language itself, (...) and so cannot be cleanly identified with any prelinguistic cognitive capacities. (shrink)

Modern Jewish philosophy emerged in the seventeenth century, with the impact of the new science and modern philosophy on thinkers who were reflecting upon the nature of Judaism and Jewish life. This collection of new essays examines the work of several of the most important of these figures, from the seventeenth to the late-twentieth centuries, and addresses themes central to the tradition of modern Jewish philosophy: language and revelation, autonomy and authority, the problem of evil, messianism, the influence of Kant, (...) and feminism. Included are essays on Spinoza, Mendelssohn, Cohen, Buber, Rosenzweig, Fackenheim, Soloveitchik, Strauss, and Levinas. Other thinkers discussed include Maimon, Benjamin, Derrida, Scholem, and Arendt. The sixteen original essays are written by a world-renowned group of scholars especially for this volume and give a broad and rich picture of the tradition of modern Jewish philosophy over a period of four centuries. (shrink)

I offer a simple method for further investigating the Interactive Specialization framework, and some data that may or may not be compatible with the approach, depending on the precise meaning of Findings from my lab indicate that, while networks of brain areas cooperate in specialized ways to support cognitive functions, individual brain areas participate in many such networks, in different cognitive domains.